Research
科研成果
量化健康以闭环式“临床需求—数据挖掘—模型开发”研发体系，与全国多家医疗机构和科研院所开展联合科研，累计 422 项联合科研项目，覆盖 116+ 种疾病。
422
项联合科研项目
116+
覆盖疾病种类
62
篇累计发表与合作论文
38
篇署名及致谢论文
01 / 研究方向
按系统分布的研究方向
| 系统 | 疾病模型数量 | 典型合作方向 |
|---|---|---|
| 神经系统 | 17 | 帕金森病、阿尔茨海默病、脑血管病、自闭症 |
| 心血管系统 | 16 | 肺动脉高压、心律失常、冠心病、高血压 |
| 消化系统 | 15 | 克罗恩病、溃疡性结肠炎、肠易激综合征、肝病 |
| 泌尿系统 | 12 | 尿路感染、泌尿系结石 |
| 风湿免疫 | 11 | 类风湿性关节炎、干燥综合征、系统性红斑狼疮 |
| 内分泌系统 | 10 | 糖尿病、甲状腺疾病、肥胖、高脂血症 |
| 呼吸系统 | 8 | 慢阻肺、哮喘、过敏性鼻炎 |
| 血液系统 | 8 | 血液系统疾病相关菌群研究 |
| 感染性疾病 | 8 | 感染与免疫相关研究 |
| 肿瘤 | 20+ | 胰腺癌、肝癌、乳腺癌、放化疗疗效相关 |
| 口腔疾病 | 5+ | 牙周炎、龋病 |
| 妇产与儿科 | 6+ | 妊娠期糖尿病、儿童发育迟缓 |
疾病模型数量为知识库统计口径；不同来源的模型/项目统计口径存在差异，以上为当前权威口径。
02 / 合作机构
合作机构
量化健康与全国多家三甲医院及科研院所保持长期合作：累计开展 422 项联合科研项目，覆盖 116+ 种疾病方向；合作内容包括临床队列的样本与数据协作、菌群与疾病的关联分析、菌株功能评价与生物信息分析支持、共同发表论文与联合申报课题等。
解放军总医院（301）
北京协和医院
阜外医院
安贞医院
宣武医院
天坛医院
佑安医院
北京朝阳医院
北京大学第一医院
北京大学第三医院
北京大学人民医院
安定医院
中日友好医院
北京儿童医院
首都儿科研究所
上海仁济医院
华西医院
北大口腔医院
北大肿瘤医院
医科院肿瘤医院
中科院微生物研究所
军事医学研究院
03 / 学术发表
论文发表
截至 2026 年 9 月，量化健康累计发表与合作论文 62 篇：其中署名及致谢论文 38 篇，另以测序、菌株与生信分析支持参与合作论文 24 篇，合作方覆盖解放军总医院、北京协和医院、阜外医院等机构。论文主题为合作研究内容，不代表公司产品或服务的适应症。
| 年份 | 期刊 | 论文标题 |
|---|---|---|
| 2026 | Genome Biology | Genome-wide association study of the cecal microbiota revealing novel genetic insights into lipid deposition |
| 2025 | Current Microbiology | Lacticaseibacillus paracasei Glu-07: A Promising Probiotic Candidate for the Management of Type 2 Diabetes Mellitus |
| 2025 | Food Frontiers | Strain-Level Screening of Human Gut Microbes Identifies Three Lactobacillus Strains as Next-Generation Antidiabetic Probiotics |
| 2025 | Phytomedicine | Neixiao-ruanmai decoction No 2 improves carotid atherosclerosis by modulating gut microbiota and inhibiting TLR4/NF-κB pathway activation |
| 2025 | Journal of Advanced Research | Whole-body mass spectrometry imaging reveals the systemic metabolic disorder and catecholamines biosynthesis alteration on heart-gut axis in heart failure rat |
| 2025 | iScience | AF6 regulates intestinal IgA via crosstalk between intestinal epithelial cells and immune cells in inflammatory bowel disease |
| 2024 | iMeta | The gut microbiota-aromatic hydrocarbon receptor (AhR) axis mediates the anticolitic effect of polyphenol-rich extracts from Sanghuangporus |
| 2024 | Food Frontiers | Therapeutic potential of dietary nutrients and medicinal foods against metabolic disorders: Targeting Akkermansia muciniphila |
| 2023 | Gut Microbes | Strain-level screening of human gut microbes identifies Blautia producta as a new anti-hyperlipidemic probiotic |
| 2023 | Scientific Reports | Lactobacillus oris improves non-alcoholic fatty liver in mice and inhibits endogenous cholesterol biosynthesis |
| 2023 | The Journal of Cachexia, Sarcopenia and Muscle | Prevotella copri alleviates sarcopenia via attenuating muscle mass loss and function decline |
| 2023 | Nutrients | Bifidobacterium as a Potential Biomarker of Sarcopenia in Elderly Women |
| 2022 | npj Biofilms and Microbiomes | Deep insights into the gut microbial community of extreme longevity in south Chinese centenarians by ultra-deep metagenomics and large-scale culturomics |
| 2022 | Biomedicine & Pharmacotherapy | The berberine-enriched gut commensal Blautia producta ameliorates high-fat diet (HFD)-induced hyperlipidemia and stimulates liver LDLR expression |
| 2022 | Biomedicine & Pharmacotherapy | Dual modulation of gut bacteria and fungi manifests the gut-based anti-hyperlipidemic effect of Coptidis Rhizoma |
| 2022 | Pharmacological Research | Cordycepin alleviated metabolic inflammation in Western diet-fed mice by targeting intestinal barrier integrity and intestinal flora |
| 2022 | PeerJ | Taxonomic and functional alterations in the salivary microbiota of children with and without severe early childhood caries (S-ECC) at the age of 3 |
| 2022 | New Microbes and New Infections | Parabacteroides pekinense sp. nov., a new bacterium isolated from the stool of a healthy man living in China |
| 2022 | 中国食品学报 | 加氏乳杆菌的降脂活性研究 |
| 2022 | Frontiers in Cellular and Infection Microbiology | Standards for Collection, Preservation, and Transportation of Fecal Samples in TCM Clinical Trials |
| 2021 | Nature Biotechnology | Voices of biotech leaders |
| 2021 | Frontiers in Microbiology | Characterization of Shallow Whole-Metagenome Shotgun Sequencing as a High-Accuracy and Low-Cost Method by Complicated Mock Microbiomes |
| 2021 | Scientific Reports | The maintenance of microbial community in human fecal samples by a cost effective preservation buffer |
| 2021 | Thoracic Cancer | Metagenome association study of the gut microbiome revealed biomarkers linked to chemotherapy outcomes in locally advanced and advanced lung cancer |
| 2021 | Journal of Translational Medicine | The fecal microbiota of patients with pancreatic ductal adenocarcinoma and autoimmune pancreatitis characterized by metagenomic sequencing |
| 2020 | mSystems | The Gut Microbiota-Produced Indole-3-Propionic Acid Confers the Antihyperlipidemic Effect of Mulberry-Derived 1-Deoxynojirimycin |
| 2020 | European Journal of Nutrition | The combination of wheat peptides and fucoidan protects against chronic superficial gastritis and alters gut microbiota: a double-blinded, placebo-controlled study |
| 2020 | World Journal of Gastroenterology | Rifaximin improves survival in cirrhotic patients with refractory ascites: A real-world study |
| 2018 | PNAS | QTY code enables design of detergent-free chemokine receptors that retain ligand-binding activities |
上表为团队 62 篇发表与合作论文中的 29 篇代表性论文（2018—2026），含公司署名、致谢署名及参与合作研究论文；论文累计覆盖 40 余种学术期刊，包括 Nature Biotechnology、Genome Biology、PNAS、Gut Microbes、iMeta、npj Biofilms and Microbiomes、Biomedicine & Pharmacotherapy、Food Frontiers、Phytomedicine、Journal of Advanced Research 等。
04 / 科研亮点
科研亮点与标准参与
新物种发现
从健康人粪便样本中鉴定并发表肠道新物种 Parabacteroides pekinense sp. nov.（New Microbes and New Infections，2022），菌株编号 Quantibio-BCGU。
团体标准起草
T/FDSA 0155—2026《益生菌在肥胖及其代谢综合征中的功效评价》（中国食品药品企业质量安全促进会归口）起草单位之一；自有菌株 BUFX、Glu-07、BDUP 被收录于该标准附录 A 的功效菌株号清单。
国家课题
联合承担国家《抗衰老益生菌靶向筛选及制备关键技术》关键技术攻关项目（联合中国农业大学、北京工商大学、伊利等）。
知识产权
累计已授权发明专利 22 项，覆盖血糖、血脂、尿酸、情绪等功能方向；另有 PCT 国际申请。
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